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Many countries have their own hemodialysis (HD) quality assurance programs and star rating systems for HD facilities. However, the effects of HD quality assurance programs on patient mortality are not well understood. Therefore, in the present study, the effects of the Korean HD facility star rating on patient mortality in maintenance HD patients were evaluated. Methods: This longitudinal, observational cohort study included 35,271 patients receiving HD treatment from 741 facilities. The fivestar ratings of HD facilities were determined based on HD quality assessment data from 2015, which includes 12 quality measures in structural, procedural, and outcome domains. The patients were grouped into high (three to five stars) and low (one or two stars) groups based on HD facility star rating. Cox proportional hazards model was used to evaluate the effects of star rating on patient mortality during the mean follow-up duration of 3 years. Results: The patient ratio between high and low HD facility star rating groups was 82.0% vs. 18.0%. The patients in the low star rating group showed lower single-pool Kt/V and higher calcium and phosphorus levels compared with subjects in the high star rating group. After adjusting for sociodemographic and clinical parameters, the HD facility star rating independently increased the mortality risk (hazard ratio, 1.11; 95% confidence interval, 1.04–1.18; p = 0.002). Conclusion: The HD facilities with low star rating showed higher patient mortality.
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It is important for the dialysis specialist to provide essential and safe care to hemodialysis (HD) patients. However, little is known about the actual effect of dialysis specialist care on the survival of HD patients. We therefore investigated the influence of dialysis specialist care on patient mortality in a nationwide Korean dialysis cohort. Methods: We used an HD quality assessment and National Health Insurance Service claims data from October to December 2015. A total of 34,408 patients were divided into two groups according to the proportion of dialysis specialists in their HD unit, as follows: 0%, no dialysis specialist care group, and ≥50%, dialysis specialist care group. We analyzed the mortality risk of these groups using the Cox proportional hazards model after matching propensity scores. Results: After propensity score matching, 18,344 patients were enrolled. The ratio of patients from the groups with and without dialysis specialist care was 86.7% to 13.3%. The dialysis specialist care group showed a shorter dialysis vintage, higher levels of hemoglobin, higher single-pool Kt/V values, lower levels of phosphorus, and lower systolic and diastolic blood pressures than the no dialysis specialist care group. After adjusting demographic and clinical parameters, the absence of dialysis specialist care was a significant independent risk factor for all-cause mortality (hazard ratio, 1.10; 95% confidence interval, 1.03–1.18; p = 0.004). Conclusion: Dialysis specialist care is an important determinant of overall patient survival among HD patients. Appropriate care given by dialysis specialists may improve clinical outcomes of patients undergoing HD.
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Background@#Pneumonia, which is the third leading cause of death in South Korea, is continuously increasing with the aging society. The Health Insurance Review and Assessment of South Korea conducted a quality assessment (QA) for improving the outcome of community-acquired pneumonia (CAP). @*Methods@#We conducted a nationwide cross-sectional study of hospitalized CAP in South Korea. First to third QA data were gathered into a single database. The national health insurance database was merged with the QA database for analyzing the medical claims data. Comorbidities, pneumonia severity, and pneumonia care appropriateness were calculated using Charlson comorbidity index (CCI), CURB-65, and core assessment of CAP scores (CAP scores), respectively. @*Results@#Overall, 54,307 patients were enrolled. The CAP scores significantly improved on QA program implementation (P < 0.001). All the variables demonstrated an association with in-hospital mortality, hospital length of stay (LOS), and 30-day mortality in the univariate analyses. Following the adjustments, higher CCI and CURB-65 scores were associated with higher in-hospital mortality, longer hospital LOS, and higher 30-day mortality. Male sex was associated with higher in-hospital/30-day mortality and shorter hospital LOS. Higher CAP scores were associated with shorter hospital LOS (P < 0.001). Upon QA program implementation, in-hospital mortality (P < 0.001), hospital LOS (P < 0.001), and 30-day mortality (P < 0.001) improved. @*Conclusion@#Continuing QA program is effective in improving the clinical outcomes of hospitalized CAP.
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Background@#F-18 Fluorodeoxyglucose positron emission tomography (F-18 FDG PET), which can cover the body from the skull base to the thigh in one scan, is beneficial for evaluating distant metastasis. F-18 FDG PET has interested policymakers because of its relatively high cost. This study investigated the effect of the F-18 FDG PET reimbursement criteria amendment on healthcare behavior in breast cancer using an interrupted time series (ITS) analysis. @*Methods@#We retrospectively analyzed the inpatient and outpatient data from Korea’s Health Insurance Review and Assessment Service (HIRA) from January 1, 2013 to December 31, 2018. ITS analysis was performed for the number of each medical imaging modality and the total medical imaging cost of the breast cancer patients. @*Results@#The annual number of breast cancer patients has been increasing steadily since 2013. The trend of F-18 FDG PET increased before the reimbursement criteria was amended, but intensely decreased immediately thereafter. The chest and abdomen computed tomography scans showed a statistically significant increase immediately after the amendment and kept steadily increasing. A change in the total medical imaging cost for the breast cancer patient claimed every month showed an increasing trend before the amendment (β = 5,475, standard error [SE] = 1,992, P = 0.008) and rapid change immediately after (β = −103,317, SE = 16,152, P < 0.001). However, there was no significant change in the total medical imaging cost at the long-term follow-up (β = −912, SE = 1,981, P = 0.647). @*Conclusion@#Restriction of health insurance coverage for cancer may affect healthcare behaviors. To compensate for it, the policymakers must consider this and anticipate the impact following implementation.
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Background@#The number of patients requiring dialysis is increasing worldwide, and the atrial fibrillation and atrial flutter (AF) prevalence among hemodialysis (HD) patients is higher than in the general population. There have been no studies of Korean AF patients undergoing HD that investigated how AF affects outcomes, such as all-cause mortality, hospitalization, and stroke events. We conducted a large-scale retrospective cohort study with data from the National Health Insurance System to determine how AF affects these outcomes. @*Methods@#In 2013, the Health Insurance Review and Assessment service, a Korean national health insurance scheme, collected data from 21,839 HD patients to evaluate the adequacy of dialysis centers. All-cause mortality, hospitalization, and stroke events were compared between patients with and without AF. Sub-analyses compared these outcomes between AF patients receiving warfarin and those not receiving warfarin. @*Results@#Cox regression analysis found that AF was a significant risk factor for death from any cause (hazard ratio [HR], 1.356; 95% confidence interval [CI], 1.222–1.506; p < 0.001), hospitalization (HR, 1.323; 95% CI, 1.225–1.430; p < 0.001), and hemorrhagic stroke (HR, 1.500; 95% CI, 1.050–2.141; p = 0.026). AF was not significantly associated with an increased risk of ischemic stroke. The use of warfarin was significantly associated with hemorrhagic stroke incidence (HR, 1.593; 95% CI, 1.075–2.360; p = 0.020), while there was no significant correlation between warfarin treatment and all-cause mortality, hospitalization, and ischemic stroke. @*Conclusion@#This cohort study of Korean dialysis patients showed that AF was a risk factor for multiple outcomes among HD patients.
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Background@#The number of patients requiring dialysis is increasing worldwide, and the atrial fibrillation and atrial flutter (AF) prevalence among hemodialysis (HD) patients is higher than in the general population. There have been no studies of Korean AF patients undergoing HD that investigated how AF affects outcomes, such as all-cause mortality, hospitalization, and stroke events. We conducted a large-scale retrospective cohort study with data from the National Health Insurance System to determine how AF affects these outcomes. @*Methods@#In 2013, the Health Insurance Review and Assessment service, a Korean national health insurance scheme, collected data from 21,839 HD patients to evaluate the adequacy of dialysis centers. All-cause mortality, hospitalization, and stroke events were compared between patients with and without AF. Sub-analyses compared these outcomes between AF patients receiving warfarin and those not receiving warfarin. @*Results@#Cox regression analysis found that AF was a significant risk factor for death from any cause (hazard ratio [HR], 1.356; 95% confidence interval [CI], 1.222–1.506; p < 0.001), hospitalization (HR, 1.323; 95% CI, 1.225–1.430; p < 0.001), and hemorrhagic stroke (HR, 1.500; 95% CI, 1.050–2.141; p = 0.026). AF was not significantly associated with an increased risk of ischemic stroke. The use of warfarin was significantly associated with hemorrhagic stroke incidence (HR, 1.593; 95% CI, 1.075–2.360; p = 0.020), while there was no significant correlation between warfarin treatment and all-cause mortality, hospitalization, and ischemic stroke. @*Conclusion@#This cohort study of Korean dialysis patients showed that AF was a risk factor for multiple outcomes among HD patients.
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BACKGROUND AND OBJECTIVES: Several studies have reported the benefits of olfactory training (OT) for patients with olfactory dysfunction. However, training odorants should be customized according to the characteristics of individual patients. The aim of this study was to evaluate the effects of OT using odorants familiar to Korean patients with post-upper respiratory infection (URI) olfactory dysfunction. SUBJECTS AND METHOD: We prospectively evaluated patients with post-URI olfactory loss. We carried out OT over a period of 6 months using four odorants: pine, cinnamon, lemon, and peppermint. Olfaction was tested before and at 1, 3, and 6 months after training initiation using the following olfactory tests; Butanol threshold test (BTT), Cross-Cultural Smell Identification Test (CCSIT) and Visual Analog Scale (VAS), Nasal Obstruction Symptom Evaluation (NOSE) scale, Sino-Nasal Outcome Test (SNOT-20), and Beck Depression Inventory (BDI). RESULTS: Of the 88 patients who initially enrolled, 82 completed the BTT, CCSIT, VAS, NOSE, SNOT-20, and BDI. In total, 10 Korean patients were included in our analysis, nine of whom showed an improvement in olfaction after OT. All patients reported changes in olfaction and the perception of smells over the duration of OT. Some patients reported an increased sense of smell after OT, although he could not distinguish different smells. CONCLUSION: OT using odorants specifically selected for Korean patients resulted in improved olfactory function, as indicated by the BTT and CCSIT scores. The findings of the present study suggest that customization of odorants to fit the characteristics of patients, including ethnicity, environment, and race, among others, increases the effectiveness of OT.
Subject(s)
Humans , Cinnamomum zeylanicum , Racial Groups , Depression , Mentha piperita , Methods , Nasal Obstruction , Nose , Odorants , Olfaction Disorders , Prospective Studies , Regeneration , Smell , Symptom Assessment , Visual Analog ScaleABSTRACT
PURPOSE: Interleukin (IL)-9 induces allergic responses; however, the roles of anti-IL-9 antibody in the induction of tolerance remain unclear. This study investigated the effects of anti-IL-9 antibody on oral tolerance (OT) in a mouse model of allergic rhinitis (AR). METHODS: BALB/c mice were divided into 4 groups: the control, AR, OT, and OT with anti-IL-9 antibody (OT+IL9AB) groups. Ovalbumin (OVA) was used for sensitization and challenge. Mice in the OT and OT+IL9AB groups were fed OVA for immunotherapy. During immunotherapy, OT+IL9AB mice were injected with anti-IL-9 antibody. Allergic symptoms, tissue eosinophil counts, and serum OVA-specific immunoglobulin E (IgE) were measured. The mRNA expressions of cytokines and transcription factors of T cells of nasal mucosa were determined by real-time polymerase chain reaction (PCR). The protein levels of GATA3, ROR-γt, and Foxp3 in nasal mucosa were determined by Western blot. CD4⁺CD25⁺Foxp3⁺ T cells in the spleen were analyzed by flow cytometry. RESULTS: Administration of anti-IL-9 antibody decreased allergic symptoms, OVA-specific IgE levels, and eosinophil counts. In addition, it inhibited T-helper (Th) 2 responses, but had no effect on Th1 responses. Protein levels of ROR-γt and mRNA levels of PU.1 and ROR-γt were reduced by anti-IL-9 antibody. Anti-IL-9 antibody increased Foxp3 and IL-10 mRNA expression, Foxp3 protein, and induction of CD4⁺CD25⁺Foxp3⁺ T cells. CONCLUSIONS: Anti-IL-9 antibody decreased allergic inflammation through suppression of Th2 and Th17 cells. Anti-IL-9 antibody enhanced the tolerogenic effects of regulatory T cells. These results suggest that anti-IL-9 antibody might represent a potential therapeutic agent for allergen immunotherapy in patients with uncontrolled allergic airway disease.
Subject(s)
Animals , Humans , Mice , Blotting, Western , Cytokines , Desensitization, Immunologic , Eosinophils , Flow Cytometry , Immunoglobulin E , Immunoglobulins , Immunotherapy , Inflammation , Interleukin-10 , Interleukin-9 , Interleukins , Nasal Mucosa , Ovalbumin , Ovum , Real-Time Polymerase Chain Reaction , Rhinitis, Allergic , RNA, Messenger , Spleen , T-Lymphocytes , T-Lymphocytes, Regulatory , Th17 Cells , Transcription FactorsABSTRACT
PURPOSE: Serine protease inhibitors are involved in immune development, anti-inflammatory mechanisms, and tissue repair. In the present study, the serine protease inhibitor 4-(2-aminoethyl) benzene sulfonyl fluoride hydrochloride (AEBSF) was evaluated for its prophylactic and therapeutic applications in a mouse model of allergic rhinitis (AR). METHODS: BALB/c mice were divided into 5 groups: contol (CON), Dermatophagoides farinae (Derf), AR mice treated with AEBSF before sensitization (S), AR mice treated with AEBSF after challenge (C), and steroid groups. Derf was used as an allergen. AEBSF was administered before S or after C. Allergic symptom scores, eosinophil counts, proteolytic activity, interferon-gamma, interleukin (IL)-10 levels and serum Derf-specific IgE levels were measured. T-bet, GATA-3, Foxp3, IL-13, and transforming growth factor (TGF)-beta mRNA levels were determined using real-time polymerase chain reaction. CD4+CD25+Foxp3+ T cells were assessed using flow cytometry. RESULTS: Symptom scores, serum Derf-specific IgE levels, GATA-3 mRNA levels, IL-13 mRNA levels, and tissue eosinophil counts decreased in both the S and C groups (P<0.05). Additionally, the percentage of CD4+CD25+Foxp3+ T cells, IL-10 levels, and Foxp3 mRNA levels increased in the S and C groups compared with those in the Derf group (P<0.05). AEBSF treatment decreased the proteolytic activity in the S and C groups (P<0.05). CONCLUSIONS: Prophylactic and therapeutic treatment with AEBSF significantly reduces allergic airway inflammation and can induce regulatory T cells in a murine model of AR.
Subject(s)
Animals , Mice , Benzene , Dermatophagoides farinae , Eosinophils , Flow Cytometry , Fluorides , Immunoglobulin E , Inflammation , Interferon-gamma , Interleukin-10 , Interleukin-13 , Interleukins , Models, Animal , Pyroglyphidae , Real-Time Polymerase Chain Reaction , Rhinitis , RNA, Messenger , Serine Proteases , Serine Proteinase Inhibitors , T-Lymphocytes , T-Lymphocytes, Regulatory , Transforming Growth FactorsABSTRACT
BACKGROUND AND OBJECTIVES: Allergic rhinitis is closely related to asthma. The skin prick test is an essential diagnostic tool for allergic disease. We evaluated differences in skin sensitization patterns between groups of patients with allergic rhinitis or asthma, or allergic rhinitis with asthma, in Korea. MATERIALS AND METHODS: From 2000 to 2009, patients with positive results from skin prick testing were divided into three groups: allergic rhinitis (AR), allergic asthma (AS), and allergic rhinitis with allergic asthma (AR+AS). We analyzed demographic data, rhinitis and asthma symptoms, and sensitization patterns. RESULTS: The most common aeroallergen was the house dust mite. The age distributions of the three disease groups differed significantly. Sensitization number, sensitization index, and atopy index were all significantly higher among the AR+AS group than among the AR or AS groups. CONCLUSION: Patients with allergic rhinitis with high numbers of skin sensitizations or intensive positivities should be considered to have concomitant asthma or to be at high risk for asthma development.
Subject(s)
Humans , Age Distribution , Asthma , Korea , Pyroglyphidae , Rhinitis , Rhinitis, Allergic, Perennial , SkinABSTRACT
BACKGROUND AND OBJECTIVES: Superantigens such as Staphylococcus aureus exotoxin (SE) have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyposis (NP). The aim of this study was to determine the immunologic response of peripheral blood mononuclear cells (PBMCs) to staphylococcal exotoxin B (SEB) in patients with NP. METHODS: The interleukin (IL)-4, IL-5, and interferon-gamma(IFN-gamma) responses of PBMCs to nonspecific mitogens such as phylohemagglutin (PHA) and SEB were examined in 24 NP patients and 16 control subjects. The presence or absence of atopy and asthma was determined to evaluate the correlation of these conditions with the levels of cytokines. RESULTS: PBMCs from the NP patients were more likely to produce IL-4 and IL-5 in response to SEB than those from controls. There was no difference in the mitogen-induced cytokine responses between NP patients and controls. SEB-induced IL-5 and IL-4 levels were higher in patients with NP with asthma than in patients with NP without asthma. CONCLUSION: Patients with NP show an exaggerated Th2 cytokine response of PBMCs to SEB.
Subject(s)
Humans , Asthma , Exotoxins , Interleukin-4 , Interleukin-5 , Interleukins , Mitogens , Staphylococcus , Staphylococcus aureus , SuperantigensABSTRACT
BACKGROUND AND OBJECTIVES: There are increasing evidence suggesting that the endoscopic approach can be used successfully for the treatment of benign sinonasal tumors. In the present study, we reviewed a 12-year experience of our institution for endoscopic management of benign sinonasal tumors. MATERIALS AND METHODS: We retrospectively reviewed the medical records and radiologic findings of 185 patients who underwent endonasal endoscopic resection of benign sinonasal tumors at the Catholic Medical Center between 1996 and 2007. RESULT: Inverted papilloma (119 cases, 64.3%) was most common, followed by hemangioma (14 cases), pyogenic granuloma (11 cases), angiofibroma (9 cases), and osteoma (7 cases). The most common symptom was nasal obstruction (70.8%). Sixteen cases (8.6%) recurred after endoscopic resection (12 cases of inverted papilloma, 2 cases of ossifying fibroma, and 2 cases of fibrous dysplasia). No major complications were reported. CONCLUSION: Endoscopic approach allows for successful surgical outcomes and good cosmetic effects among patients with benign sinonasal tumors. We suggest that, in selected cases, benign tumors involving the sinonasal tract can be safely and radically removed using the endoscopic technique.
Subject(s)
Humans , Angiofibroma , Cosmetics , Endoscopy , Fibroma, Ossifying , Granuloma, Pyogenic , Hemangioma , Medical Records , Nasal Obstruction , Nose , Osteoma , Papilloma, Inverted , Paranasal Sinuses , Retrospective StudiesABSTRACT
Pneumoparotid is a rare, but well reported disease. It is caused by increased intraoral pressure. Cough, wind instrument playing, ballooning of cheek and nervous tics may increase intraoral pressure. We recently experienced a interesting case of pneumoparotid after lifting of heavy luggage. A 20-year-old man was suffering from enlargement of left parotid area, heating sensation of left cheek, bilateral hearing impairment and click sound when he opened mouth. In spite of intravenous antibiotics and antiinflammatory drug administration and conservative treatment including warm compression, massage and hydration, the enlargement of left parotid was not improved. So we performed the ligation of left Stensen's duct under local anesthesia. His symptoms subsided after operation. Now, the patient continues to be observed without any trouble.
Subject(s)
Humans , Young Adult , Anesthesia, Local , Anti-Bacterial Agents , Cheek , Cough , Hearing Loss , Heating , Hot Temperature , Lifting , Ligation , Massage , Mouth , Parotid Gland , Salivary Ducts , Sensation , Stress, Psychological , Tics , WindABSTRACT
Objective tinnitus which may be caused by contraction of the tensor tympani and stapedial muscles is extremely rare. We present a case of middle ear myoclonus with voluntary palatal myoclonus in a musician. Otologic examination demonstrated rhythmic involuntary movement of the tympanic membrane after the exposure of loud sound or blowing of the musical instrument. Impedance audiometry confirmed the motion of tympanic membrane and those movements correlated with a tinnitus perceived by the patient. Palatal myoclonic motion, voluntarily evoked by the patient, was observed by oral examination and heard by Toynbee tube objectively. Medical treatment and directive counseling were effective for voluntary palatal myoclonus. However, the main symptom of tinnitus caused by middle ear myoclonus was not changed. The patient's tinnitus was cured by tympanotomy with sectioning of the tensor tympani and stapedial tendons.
Subject(s)
Humans , Acoustic Impedance Tests , Diagnosis, Oral , Directive Counseling , Dyskinesias , Ear, Middle , Muscles , Music , Myoclonus , Tendons , Tensor Tympani , Tinnitus , Tympanic MembraneABSTRACT
Wegener's granulomatosis is a granulomatous inflammatory process with necrotizing vasculitis. It can involve any organ in body, but primarily affects upper and lower respiratory tracts or kidney. We recently experienced an interesting case of Wegener's granulomatosis presenting as bilateral facial paralysis. A 54-year-old man was suffering from nasal stuffiness and rhinorrhea and treated with antibiotics. In spite of the treatment, the nasal symptoms were aggravated and left facial paralysis was developed suddenly with left hearing impairment. Diagnosis as Wegener's granulomatosis was supported by biopsy from nasal cavity. He underwent medical therapy with prednisone and cyclophosphamide. About 3 months after development of left facial paralysis, right facial paralysis was emerged abruptly. At 6 months after discharge, his facial nerve continued to function at a House-Brackmann grade III level.
Subject(s)
Humans , Middle Aged , Anti-Bacterial Agents , Biopsy , Cyclophosphamide , Diagnosis , Facial Nerve , Facial Paralysis , Hearing Loss , Kidney , Nasal Cavity , Prednisone , Respiratory System , Vasculitis , Granulomatosis with PolyangiitisABSTRACT
BACKGROUND AND OBJECTIVES: The status of cervical lymph node and its treatment has a great influence on the prognosis of the patient with tongue cancer. We were to analyze the outcomes of treatment in patients with N0 tongue cancer, and the incidence and pattern of neck metastasis. SUBJECTS AND METHOD: The medical records of 50 patients with N0 tongue cancer who had surgical treatment performed at the department of Otolaryngology-HNS, College of Medicine, the Catholic University of Korea, between 1994 and 2006 were reviewed. All patients were treated surgically: 45 patients went through had neck dissection and 5 patients went through sentinel node biopsy. RESULTS: The overall rate of occult neck metastasis was 17.8% (8 of 45). The pathologic T stage with occult neck metastasis were 3 cases in T1, 4 cases in T2, and 1 case in T3. The local recurrence rate was 12%. The overall regional recurrence rate was 8%. The regional recurrence rate of neck dissection group and sentinel LN biopsy group were 6.7% (3 of 45) and 20.0% (1 of 5), respectively. The depth of invasion in T2 cases of the regional recurring group was deeper than in T2 cases of the non-regional recurring group. CONCLUSION: In clinical N0 tongue cancer, due to the relatively high overall occult metastasis rate and low recurrence rate at the neck node after the neck dissection, the elective neck dissection should be considered especially in deep tumor invasion cases.
Subject(s)
Humans , Biopsy , Incidence , Korea , Lymph Nodes , Lymphatic Metastasis , Medical Records , Neck , Neck Dissection , Neoplasm Metastasis , Prognosis , Recurrence , Tongue Neoplasms , TongueABSTRACT
BACKGROUND AND OBJECTIVES: The purpose of this study were to evaluate the therapeutic efficacy of canalith repositioning maneuver (CRP) according to accompanying mastoid percussion and to investigate the prognostic factors that may affect successful repositioning maneuver and the recurrence of benign paroxysmal positional vertigo. MATERIALS AND METHOD: A total of 70 patients with canalith type BPPV visiting the dizziness clinic of Kangnam St. Mary's Hospital were included in this study. Variables identified for statistical analysis were patient's age, sex, maneuver method, number of involved canal, number of CRP and dizziness handicap inventory. RESULT: Overall success rate of CRP was 90%. The mean number of maneuver was 1.6 and the recurrence rate was 25.7% during the follow up period. Success rate of CRP (94.9%) was higher than maneuver without mastoid percussion (83.9%) though it was not statistically significant. Successful CRP group showed the significant less number of maneuvers at initial treatment session and less number of involved canal than failed CRP group at the time of one week-follow up visit. Patients with recurrence of BPPV had the more number of CRP during the period of previous BPPV. CONCLUSION: Therapeutic efficacy of CRP with mastoid percussion was higher than CRP without mastoid percussion though it was not statistically significant. Suggesting prognostic factors for effective CRP and recurrence were number of CRP and number of involved canal.
Subject(s)
Humans , Dizziness , Follow-Up Studies , Mastoid , Percussion , Prognosis , Recurrence , VertigoABSTRACT
BACKGROUND AND OBJECTIVES: Mast cells are the main effector cells in the immediate phase of the allergic responses. To evaluate the role of mast cells on the development of allergen-induced eosinophilic inflammation in a murine model of allergic rhinitis(AR), we compared the responses of mast cell deficient (W/Wv) mice with congenial normal (W/W+) mice. MATERIALS AND METHOD: Mice were sensitized intranasally with an extract of Aspergillus fumigatue (Af) for 3 weeks, and challenged intranasally with a single dose (acute model) or single dose every day for 5 consecutive days (chronic model). Interleukin (IL)-5 in nasal lavage fluids (NLF), histologic examination and Af-specific immunoglobulins (Ig) were examined in W/Wv mice and W/W+mice. RESULTS: In the sensitized W/Wv mice, the number of eosinophils in the nasal mucosa and IL-5 in NLF after repeated allergen challenge were not significantly different from those of W/W+ mice. In contrast, the number of eosinophils in the nasal mucosa and IL-5 in NLF after single allergen challenge were partially attenuated in W/Wv mice. The levels of Af-specific IgE and IgG1 in both acute and chronic models were not different between W/Wv mice and W/W+ mice. CONCLUSION: These findings suggest that eosinophilic inflammation caused by repeated allergen challenge are independent of mast cells in this AR model.